propionyl chloride
propionyl chloride
CAS: 79-03-8
Molecular Formula: C3H5ClO
propionyl chloride - Names and Identifiers
| Name | propionyl chloride |
| Synonyms | AKOS BBS-00004085 PROPANOYL CHLORIDE PROPIONYL CHLORIDE propionyl chloride Propanoyl chloride PROPIONIC ACID CHLORIDE Propionyl Chloride Factory Price PROPIONYL CHLORIDE FOR SYNTHESIS Propionyl chloride Propanoyl chloride |
| CAS | 79-03-8 |
| EINECS | 201-170-0 |
| InChI | InChI=1/C3H5ClO/c1-2-3(4)5/h2H2,1H3 |
| InChIKey | RZWZRACFZGVKFM-UHFFFAOYSA-N |
propionyl chloride - Physico-chemical Properties
| Molecular Formula | C3H5ClO |
| Molar Mass | 92.52 |
| Density | 1.059 g/mL at 25 °C (lit.) |
| Melting Point | -94 °C |
| Boling Point | 77-79 °C (lit.) |
| Flash Point | 53°F |
| Water Solubility | REACTS |
| Vapor Presure | 106 hPa (20 °C) |
| Vapor Density | 3.2 (vs air) |
| Appearance | Liquid |
| Color | Clear |
| Exposure Limit | ACGIH: TWA 0.1 ppmOSHA: TWA 0.1 ppm(0.4 mg/m3)NIOSH: IDLH 2 ppm; TWA 0.1 ppm(0.4 mg/m3); Ceiling 0.2 ppm(0.8 mg/m3) |
| Merck | 14,7828 |
| BRN | 385632 |
| Storage Condition | Store below +30°C. |
| Sensitive | Moisture Sensitive |
| Explosive Limit | 3.6-11.9%(V) |
| Refractive Index | n20/D 1.404(lit.) |
| Physical and Chemical Properties | Colorless liquid, pungent odor boiling point 80 ℃ freezing point -94 ℃ relative density 1.065 refractive index 1.4032 flash point 12 ℃ soluble in ethanol |
| Use | The pharmaceutical industry is used in the production of The antiepileptic drug metol, the antiadrenergic agent methoxamine hydrochloride, used as propionyl reagent in organic synthesis |
propionyl chloride - Risk and Safety
| Risk Codes | R11 - Highly Flammable R14 - Reacts violently with water R34 - Causes burns R20/22 - Harmful by inhalation and if swallowed. |
| Safety Description | S9 - Keep container in a well-ventilated place. S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1815 3/PG 2 |
| WGK Germany | 1 |
| RTECS | UG6657000 |
| TSCA | Yes |
| HS Code | 29399990 |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 823 mg/kg |
propionyl chloride - Upstream Downstream Industry
| Raw Materials | Propionic acid Propionic acid |
propionyl chloride - Nature
Open Data Verified Data
colorless liquid with pungent odor. Soluble in ethanol, decomposition in water. The relative density was 1. 065. The boiling point was 80 °c. Freezing point -94 °c. Refractive index 4032. Flash point 12 ℃.
Last Update：2024-01-02 23:10:35
propionyl chloride - Preparation Method
Open Data Verified Data
- The propionic acid of phosphorus trichloride method reacts with phosphorus trichloride at 45 ° C., and the reaction product is condensed and rectified to obtain a finished product.
- The benzoyl chloride method results from the interaction of propionic acid with benzoyl chloride.
Last Update：2022-01-01 10:32:20
propionyl chloride - Use
Open Data Verified Data
The pharmaceutical industry is used for the production of antiepileptic drug metol, cholerol and antiadrenergic agent methoxamine hydrochloride; The pesticide industry is used for the production of trichlorfon; It is used as propionyl reagent in organic synthesis; it is also an intermediate for the preparation of various propionic acid derivatives, such as phenylacetone and the like.
Last Update：2022-01-01 10:32:19
propionyl chloride - Safety
Open Data Verified Data
- This product has strong toxicity and irritation, extremely strong irritation to the skin and mucous membranes, and even cause burns. Water decomposition, produce hydrogen chloride. Production equipment should be closed, the site should have good ventilation conditions. The operator should wear labor protection articles.
- packaging should be sealed, heat-proof, moisture-proof. It is generally used as an intermediate for self-use. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:32:20
propionyl chloride - Reference Information
| pH range | <7.0 |
| freezing point | -94 ℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | propionyl chloride is an intermediate of the plant growth regulator cyclic acid. The pharmaceutical industry is used for the production of anti-epileptic drugs metuine, anti-adrenergic drugs methoxamine hydrochloride, used as propionyl reagent in organic synthesis used as alkylating reagent used as propionyl reagent in organic synthesis, which is an intermediate for preparing various propionic acid derivatives, such as phenylacetone; used in the production of pesticides; Pharmaceutical industry for the production of anti-epileptic drug metaxol, choleretic alcohol, anti-adrenergic agents such as methoxamine hydrochloride. |
| production method | propionic acid can be reacted with phosphorus trichloride, phosphorus pentachloride, thionyl chloride or phosgene to produce propionyl chloride. 1. Propionic acid and phosphorus trichloride were put into a reaction Pan, several magnetic pieces were added, and the mixture was refluxed at 50 ° C. For 6H. After standing for 1-2H, the lower phosphorous acid was separated to obtain propionyl chloride. Under the condition of 1.32:1 propionic acid: PCl3, the yield was 95%. When the crude product needs to be purified, the method of distillation can be used, and the fraction of about 80 ° C can be collected to obtain the finished product. Raw material consumption quota: propionic acid (99.5%)990kg/t, phosphorus trichloride (98%)690kg/t. The benzoyl chloride method is derived from the interaction of propionic acid with benzoyl chloride. The preparation method is to react propionic acid with phosphorus trichloride at 40-50 ℃ for 1H, cool, stand, separate and distilled to obtain the product. Reaction equation: CH3CH2COOH + PCl3 → CH3CH2COCl + HOPCl2 |
| spontaneous combustion temperature | 270°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:11
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Raw Materials for propionyl chloride